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    Job details

Offer: MPhil/PhD Studentship available full time and part-time: Pre-clinical Targets for Vascular De:

Job description:

Qualification Type: PhD
Job location: Plymouth
Funding for: UK Students, EU Students
Funding amount: £15,009 per annum
Hours: Full Time

Published in: 11th September 2019
Closing date: 6th October 2019
Listing reference: 19-20-006


Start date: Jan 2020
Dos: Professor Robert Fern
2nd manager: Edgar Kramer
3rd manager: Konstantin Glebov
The University of Plymouth's Faculty of Health: Medicine, Dentistry and Human Sciences is seeking a highly motivated PhD candidate with outstanding abilities. Medical research in the Faculty was ranked first for outputs in REF2014.
White matter makes up about half of the human brain, but we know little about the function of white matter in disease. White matter changes occur early in a number of important neurological disorders and this studentship will focus on a particularly clear example, vascular dementia. Vascular dementia is the second most common form of dementia and arises primarily from ischemic-type injury to white matter. Our laboratory has shown the important function that glutamate receptors have in white matter injury and the prosperous candidate will use ectrophysiological, myelin imaging and electron microscopy techniques to describe the functional and structural effects of focal WM injury in a novel in vitro model, and the protective effect of potential clinical interventions located on glutamate receptor antagonists. The most prosperous strategy will subsequently be tested in an in vivo model of dementia. The student will gain expert technical expertise in electrophysiology, live cell imaging and electron microscopy, attaining a range of expertise appropriate for a career in dementia research.
For greater technical detail of the approaches to be used please see:
   » Doyle, S. Hansen, D. Vella, J. Bond, P. Harper, G. Valentino, M. Fern, R. (2018) Vesicular glutamate release from central axons contributes to myelin damage. Nature communications , 9:1032: 1-15.
   » Jackson, J. Bianco, G. O Rosa, A. Cowan, K. Bond, P. Anichtchik, O and Fern, R. (2018) White matter tauopathy: transient functional loss and novel myelin remodeling. Glia , 66: 813-827.
For more information regarding the project, Contact Us by Professor Robert Fern (
Funding Notes: The studentship is supported for 3 years and includes full Home/EU tuition fees, plus a stipend of an estimated £15,009 per annum (located on 19/20 full time stipend amounts). candidates normally required to cover overseas fees will have to cover the difference between the Home/EU and the overseas tuition fee rates (£12,285 for the 19/20 academic year). If you are selected you will be required to provide financial assurances.
To Apply: Follow the link -and-enquirers and click ?Apply'. Please mark the application for the attention of Amber Strong. Please Note : You do not need to submit a project proposal with your application. If you have any questions on the admissions process contact
The closing date for applications is 12 midnight on 06/10/2019. Shortlisted candidates will be invited for interview . We regret that we may not be able to respond to all applications. candidates who have not received an offer of a place by 01/11/2019 should consider their applicant unprosperous.


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Salary: Unspecified
Degree: Unspecified
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Job Location: Plymouth, Devon England
Address: Devon
Company Type Employer
Post Date: 09/11/2019 / Viewed 5 times
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