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PhD Studentship: Novel Lab-on-a-Chip Devices for Detection of Extracellular Vesicles as Signs of Age:

Job description:

Qualification Type: PhD
Job location: Birmingham
Funding for: UK Students, EU Students
Funding amount: Not Specified
Hours: Full Time

Published in: 9th October 2019
Closing date: 31st October 2019


A PhD Studentship is available for a suitably qualified candidate to conduct research leading to the award of a PhD degree in the field of Chemical Engineering. The prosperous candidate will join the world-leading Advanced Nano-Materials, Structures and Applications (ANMSA) Group, one of the leading academic groups in the field of development of novel micro and nano-structures and miniaturised diagnostic technologies. more information can be found on the group's website:

We are an ageing society, with life expectancy increasing and birth rates falling. However, the period of life spent in good health, is not keeping pace and adults are unwell for the last ten years of their life. There is an unmet need for interventions that increase health-span and ensure people reach old age in good biological health. However, there is currently no easy way of assessing if someone is ageing well and how old someone is either biologically or chronologically that could be used in the community, with the only assay involving epigenetic assessment, that takes days and is very costly. The development of a rapid bedside device to measure biomarkers of the ageing process in readily accessible biofluids would be a major step forward for assessing individual ageing and as an accurate measure the efficacy of clinical interventions to assess individual's clinical progress towards rebuilding the ageing and diseased body. Extracellular vesicles (EVs) are membrane-derived particles of varying submicron sizes, which have been implicated as novel indicators of various age-related pathologies. EVs are increased in many age-related diseases e.g., cardiovascular and neurodegenerative, acting as supramolecular key-targets of vascular damage, and bio-messengers, disseminating biological signals all over tissues and promoting inflammation. This project will involve designing and developing unique optofluidic Raman lab-on-a-chip via novel nanophotonic-sensing platforms for detection and analysis of EV, indicative of ageing and the connected diseases.

We are seeking for a highly motivated, bright and enthusiastic candidate. The research is of an interdisciplinary nature and lies at the interface of physical science, engineering and biomaterials and will explore development and implementation of advanced, cost-effective and versatile patterning techniques as well as ways to establish appliccapability of patterned surfaces and their integration in miniaturised integrated microfluidic surface enhanced Raman scattering systems for point-of-care detection. The superior detection properties and the capability to fabricate lab-on-a-chip on the miniaturised scale will be aimed to facilitate the development of advanced and novel optofluidic devices and will offer numerous applications in biomedical diagnostics.

Applications comprising a detailed CV and the names and addresses of two referees should be sent by email to Dr P. Goldberg Oppenheimer: 31.10.2019. Dr Oppenheimer would also welcome informal enquiries. The prosperous applicant will be required subsequently to submit a standard application to the University.

Closing Date: 31st of October 2019.


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Salary: Unspecified
Degree: Unspecified
Experience (year): Unspecified
Job Location: Birmingham, West Midlands England
Address: West Midlands
Company Type Employer
Post Date: 10/09/2019 / Viewed 1 times
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