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Offer: Postdoctoral Research Associate, Cancer Research:Job description:Job location: Sheffield Contract type: Fixed term until 31st May 2027 Job location: The Medical School Beech Hill Rd Sheffield S10 2RX We have a great opportunity in the School of Medicine and Population Health for a Postdoctoral Research Associate position, which is perfect for a researcher with a passion for driving biological discoveries through to development of new cancer therapeutics. It is ideally suited to an enthusiastic researcher looking to use their expertise in cancer biology, bone biology, cancer cell dormancy, translational research and/or significant fields who want to have an impact on patients with incurable cancers that grow in bone (myeloma and advanced breast and prostate cancer). We are pursuing an enthusiastic and motivated researcher to work on the first phase of an 8-year Wellcome Trust-funded award. The project will investigate how dormancy allows cancer cells to evade chemotherapy and identify weaknesses of dormant cell to enable us to develop new dormancy-targeting therapeutics. You will use clinically-significant in vitro (2D/3D) and in vivo models of multiple myeloma dormancy and chemotherapy-resistance developed by our team. You will test new dormancy and niche-targeting therapeutic approaches to kill dormant cancer cells, and perform multi-omic characterisation of dormant cells and their microenvironment to identify new therapeutic targets. You should have a PhD or be close to completion in significant biomedical fields (molecular or cell biology, cancer biology, bone biology) or have equivalent practice. You will be a highly motivated and hard-working with the capability to design, perform and analyse experiments with attention to detail and integrity. The project will include a wide variety of models and techniques, practice in cell culture and molecular biology techniques are essential, with practice in large panel flow cytometry and immunofluorescence microscopy being desirable. practice in mouse models of myeloma/cancer and/or bone would be highly desirable. practice in metabolomics and/or RNA sequencing and bioinformatics would also be highly desirable. This is a 3-year post, with potential to extend to 2032. We are committed to exploring flexible working opportunities which benefit the individual and University. We're one of the best not-for-profit organisations to work for in the UK. The University's Total compensate Package includes a competitive income, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and development courses to support your personal and professional development. We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student practice. To find out what makes the University of Sheffield a remarkable place to work, watch this short film: www.youtube.com/watch?v=7LblLk18zmo, and follow @sheffielduni and @ShefUniJobs on Twitter for more information. Apply now by clicking on the Apply button located near the top of your screen Skills:
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