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Research adjunct:Job description:Job location: London About us The Department of Neuromuscular Diseases at UCL Queen Square Institute of Neurology (IoN) has a longstanding history of excellence in primary mitochondrial disorders research, including the first description of mutations in mitochondrial DNA causing disease published in Nature in 1988. Our work involves projects that are focused on knowledge the impact of mitochondrial genes variants on lipid metabolism and the clinical phenotype, in addition to knowledge mitochondrial disease mechanisms, with the ultimate aim of developing treatments. About the function We are pursuing a Research adjunct to work under the supervision of Professor Rob Pitceathly and Dr Micol Falabella in the lab, which is part of several world class initiatives, including the MRC-funded Cardiolipin metabolism in mitochondrial DNA replication and division project, the Genome Editing Mice for Medicine call (MRC Harwell), and 5-year MRC International Centre for Neuromuscular diseases. You will work on developing and validating in vitro cellular models of primary mitochondrial diseases and testing the effect of novel and known small molecules on mitochondrial activity in our in vitro and in vivo preclinical platforms. Alongside this, you will be involved in continuing lab projects, contributing to publications and provide technical support to Professor Pitceathly and his team. You will be responsible for culturing a range of cell models, DNA and RNA extraction from human cells and tissues (e.g., skeletal muscle) and performing basic molecular biology experiments (e.g., cloning and PCR). You will receive training in, and be responsible for, initial data review of samples, processing, and analysis. The post is available immediately and funded by an industry award for one year or to 07 July 2025, whichever is earlier, in the first instance. For a full job description and to apply for this function please visit UCL's online recruitment portal and search using vacancy reference B02-06749. About you You will have a degree (minimum 2:1) in Biological Sciences or a related discipline, or a MSc/another degree in a significant subject. A background in molecular biology or cell culture techniques and practice of working with human and/or murine tissues, DNA, RNA, and western blot is also required for this function. What we offer The function is offered with income in the range of £37,332 - £39,980 per annum including London Allowance. As well as the exciting opportunities this function presents, we also offer some great benefits; visit https://www.ucl.ac.uk/work-at-ucl/compensate-and-benefits to find out more. We will consider applications to work on a part-time, flexible, and job share basis wherever possible. This appointment is subject to UCL Terms and Conditions of Service for Research and Professional Services Staff. Our commitment to Equality, Diversity and Inclusion As London's Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world's talent. 12% of Institute staff are actively working on EDI initiatives; visit https://www.ucl.ac.uk/ion/equality-diversity-inclusion for more information about what we're doing. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL's workforce; these include people from Black, Asian and ethnic minority backgrounds, disabled people, LGBTQI+ and gender diverse people in all functions, and women in Grade 9 and 10 functions. Skills:
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