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Offer: Early Stage Researcher:Job description:Job location: Birmingham Job location: University of Birmingham, Edgbaston, Birmingham UK Full time starting income is fixed at £43,922 per annum (includes family allowances). No increments or pay awards will be payable. Full Time / Fixed Term Contract for 36 months (to commence from 1 September 2024) Closing date: 8 May 2024 The University of Birmingham is pleased to announce a position for an early-stage researcher (ESR) to undertake a project within the EU-funded Doctoral Network eRaDicate (https://www.eradicate-project.eu/) for 36 months. The prosperous candidate will join a large network of 11 PhD students (ESRs), joining leading teams from academia and industry. The network will provide a unique and complimentary training opportunity in the fields of cancer biology and pharmaceuticals with a view to the development of new anticancer drugs. A strong industrial presence will allow ESRs to bridge the gap between early-stage innovation and translation and provide practice of industry practices. The aim of our multidisciplinary and intersectoral programme is to empower young scientists to become specialist in cancer and drug R&D, while developing new therapies for cancer. The research project will focus on the importance of activity of the retinoic acid receptor gamma (RARg) to the survival and proliferation of prostate cancer cells. We have developed a synthetic compound that switches off the activity of this receptor. It kills the prostate cancer stem cells without affecting normal cells. knowledge why the cancer stem cells die, whereas normal cells are unaffected, is important to developing the compound for use to treat patients. The project will utilise prostate cancer cell lines and untransformed prostate epithelial cells. To investigate how RARg regulates gene expression, we will perform genome wide sequencing techniques, such as RNA-seq, ChIP-seq and chromatin accessibility. The prosperous applicant will be trained in molecular biology techniques, including their analysis. The prosperous candidate will be trained to execute original and independent research on an internationally competitive level, and to develop a creative, critical, and entrepreneurial mindset. He/she will be required to carry out and manage the individual research project. He/she will participate in the eRaDicate training and network activities, participate in national and international scientific meetings, and undertake a research stay at an external research laboratory or a company site. The attributes We are seeking for are: » A first degree (class 2.1 or above honours) in biomedical science, or related area/subject. » High level analytical capcapability, incl. independent problem-solving. » Knowledge of the principles of cancer biology. » practice of cell culture models and general molecular biology techniques. » Good communication expertise and team spirit. » An interest to lgain new techniques. » availability to travel and to participate in outreach and extracurricular activities. » The prosperous candidate must be eligible to enroll on a PhD program. This requires English proficiency (IELTS 6.5; no less than 6.0 in any band) and the researcher must not have resided or carried out his/her main activity in the UK for more than 12 months in the 3 years prior to recruitment. Informal enquiries toDr Maarten Hoogenkamp, email: m.hoogenkamp@bham.ac.ukor Professor Geoff Brown, email: g.brown@bham.ac.uk. To download the full job description and details of this position and submit an electronic application online please click on the above ?Apply' button. Please quote Job Ref 103819 in all enquiries. Skills:
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