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Offer: Research Fellow (105145-0424):Job description:Job location: Coventry There is funding to recruit a PDRA on FA6 to 30.09.2025 with an extension up to a max 20 months subject to sufficient funding and approval from BBSRC to extend the funding beyond 30.09.2025 Plant Molecular Biologist; Plant Immunity A fixed term contract BBSRC funded Research Fellow position is available in the Grant laboratory. We seek a highly motivated cell/molecular biologist, ideally with some practice in plant immunity to work on knowledge the function of novel cyclic ADP ribose derivatives generated by the Toll-Interlukin 1 (TIR) class of plant disease resistance proteins. Remarkably, pathogens deploy TIR containing effectors to suppress disease by producing subtly different cyclic ADP ribose variants. This project will dissect how these contrasting TIR domain containing proteins affect the outcome of plant-pathogen interactions. The research uses the model pathosystemArabidopsis thaliana- P. syringaeinteraction. A collection of immune compromisedArabidopsismutants and alteredP. syringaestrains will be studied in conjunction with genetically encoded reporters, novel whole plant imaging approaches, proteomics and targeted mass-spectrometry to dissect early plant immune responses and how these are suppressed by the pathogen. While focussed on plant immunity, this project would suit anenthusiastic plant molecular/cell biologist with additional expertise in any of the areas of biochemistry, proteomics, or metabolomics. The projectinvolves collaborators in the USA and Hong Kong and benefits from Warwick's excellent including state-of-the-art imaging facilities and one of the UKs leading Mass Spectrometry facilities in Warwick's Chemistry department.The prosperous candidate will join a well-funded lab, working on a range of challenges in the plant immunity field, including systemic signalling, metabolic immunity, inter-organellular communication and the molecular basis of plant immune suppression. Any requests For more information can be directed to Murray Grant, m.grant@warwick.ac.uk. Full details of the tasks and selection criteria for this function can be found in the vacancy advert on the University of Warwick's jobs pages. You will be routed to this when you click on the Apply button. Skills:
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