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Offer: Senior Postdoctoral Scientist (2 Posts):Job description:Job location: Oxford About the function An exciting opportunity to join a multidisciplinary research team at the Oxford centre of Neuroinflammation. You are invited to apply to join Professor Lars Fugger and his team of research scientists, computational biologists, and clinicians, having access to state-of-the-art technologies and collaborating with leading researchers both locally and globally. Physical and mental discapability caused by neuroinflammation is a common clinical occurrence in many diseases, including multiple sclerosis (MS), Alzheimer's and schizophrenia. However, the cause(s) of this inflammation and the devastating consequences that ensue are poorly defined, as reflected by a lack of effective treatments. Moreover, their relatedness to inflammatory diseases outside of the central nervous system (CNS), such as inflammatory bowel disease or rheumatoid arthritis, is also unknown. We have shown how studying individual cells directly from patient blood or mapping biological events across the diseased brain in post-mortem tissue, can expose an intricate network of neuroinflammatory processes, which can change dramatically both through time and within the tissue. Importantly, we have developed great collaborations with our local and international clinical colleagues, enabling us to study these diseases directly from patient samples, which are complemented by a wealth of clinical data. Our in-house capabilities include the generation of single cell epigenetic and transcriptomic data, complemented with protein level data (CITE-seq), spatial transcriptomics, and functional validation studies, including CRISPR-editing of primary cells. About You The prosperous applicant(s) is invited to expand and build upon this exciting research platform and to dissect the underlying biology that either unites or sets complex inflammatory diseases apart. You must therefore be highly motivated and have the capability to develop new ideas and research objectives. You should have specialist expertise in the discipline to develop research projects and methodologies. You should be able to independently manage a research project and research budget, with the capability to raise research funds through making grant applications. You should hold a significant PhD / D.phil with post- qualification research practice. If you would like to discuss your application informally before applying, email Professor Fugger (lars.fugger@imm.ox.ac.uk). more information regarding the research group of Professors Lars Fugger can be found at: https://www.imm.ox.ac.uk/research/research-groups/fugger-group About the Radcliffe Department of Medicine (RDM) The Radcliffe Department of Medicine (RDM) within the Medical Sciences Division is one of the largest departments in the University of Oxford. RDM is a multi-disciplinary department which aims to tackle some of the world's biggest health challenges by integrating innovative basic biology with cutting edge clinical research. Benefits of working As an employer, we genuinely care about our employees' wellbeing and this is reflected in the range of benefits that we offer including: • An excellent contributory pension scheme • 38 days annual leave • A comprehensive range of childcare services • Family leave schemes • Cycle loan scheme • Discounted bus travel and Season Ticket travel loans • Membership to a variety of social and sports clubs See https://hr.admin.ox.ac.uk/staff-benefits for more information. Application Process ?Committed to equality and valuing diversity? The post is full time and fixed-term for 3 years. Applications to be made online. You will be required to upload a supporting statement and CV as part of your online application. The supporting statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Only applications received before 12:00 midday on 20/05/2024will be considered. Skills:
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