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Job Offer: PhD Studentship: Finding New Antibiotics in the Soil Microbiota:

Job description:

Qualification Type: PhD
Job location: Norwich
Funding for: UK Students, EU Students, International Students
Funding amount: See advert details
Hours: Full Time

Published in: 25th November 2021
Closing date: 17th January 2022
Listing reference: MALONE_J22MMB

 

The increase in drug-resistant bacterial infections is a major global health threat. This crisis is exacerbated by a lack of new antibiotics, caused by multiple factors including the frequent rediscovery of known antibiotics. The soil microbiota is a rich source of natural product molecules, with soil bacteria producing the majority of current clinical antimicrobials. The vast genetic diversity within the soil microbiota means that many novel, clinically significant natural products undoubtedly remain to be identified. However, to fully exploit this natural resource we both need to identify efficacious antimicrobials, and effectively minimise rediscovery. The genomic era provides an incredible opportunity to revitalise the antibiotic pipeline and guide the discovery of new antibiotic classes.
Our labs in the John Innes Centre, an internationally recognised centre of excellence for microbiology and plant sciences, have developed an effective, high-throughput pipeline for the identification and characterisation of biologically effective bacterial natural products. By pairing antimicrobial discovery with advanced data analysis we ensure that novel pathways and products are prioritised, and minimise antibiotic rediscovery.
In this project, the student will exploit the broad soil microbial isolate libraries and discovery pipeline emerging from our recent research to identify and characterise new, clinically efficacious antimicrobial molecules. The student will receive training in advanced molecular microbiology and bacterial genetic manipulation, alongside cutting-edge organic chemistry techniques including LC-MS-located metabolomics, bioassay-guided fractionation and structural elucidation using 2D NMR. all over the project, the student will receive broad training in the analysis of microbial genomes, statistics, phylogenetics and other bioinformatic techniques, as well as transferable soft-expertise with broad appliccapability to many employment areas.
The Microbes, Microbiomes and Bioinformatics (MMB) Doctoral Training Partnership (DTP) is open to UK and international candidates with an undergraduate degree significant to the scope of the programme for entry in October 2022 and offers postgraduates the opportunity to undertake a 4-year PhD research project funded by the UKRI Medical Research Council to advance the training of students in microbiology, with an emphasis on microbial bioinformatics.
This project has been shortlisted for funding by the MMB DTP programme. Interviews for shortlisted candidates will take place on Tuesday 15 or Wednesday 16 February 2022.
This MMB DTP is committed to equality, diversity, widening participation and inclusion in all areas of the programme. We encourage enquiries and applications from all sections of the community, regardless of gender, ethnicity, discapability, age, sexual orientation, and transgender status. We value an aptitude for computer-located analysis, curiosity, and independence of thought, plus a commitment to work across the boundaries between the laboratory and bioinformatics to deliver high-impact research. We welcome candidates from low- and middle-earnings countries.
For information on eligibility and how to apply: https://www.uea.ac.uk/research/research-with-us/postgraduate-research/lates t-phds-and-research-studentships/partnerships-in-doctoral-training
Primary manager : Dr Jacob Malone (JIC)
Start date: 1 October 2022
For more information on this project, please visit http://www.uea.ac.uk
This project is awarded with a 4-year MMB DTP PhD studentship, which includes support for a maintenance stipend, provided over four years, full tuition fees and research and training costs.
Studentship funding will not normally cover costs connected with visa or health surcharges, or additional costs connected with entry to, and living in the UK.

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Salary: Unspecified
Degree: Unspecified
Experience (year): Unspecified
Job Location: Norwich, Norfolk Other
Address: Norfolk
Company Type Employer
Post Date: 11/25/2021 / Viewed 1 times
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