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Offer: Proposed Project Title: Fractional-order pharmacokinetics: model parameter identification and:Job description:Qualification Type: PhD Principal manager (s): Dr Pantelis Sopasakis Contact Details: Email: p.sopasakis@qub.ac.uk Second manager: Dr Nikolaos Athanasopoulos Proposed Project Title: Fractional-order pharmacokinetics: model parameter identification and optima drug administration Project Introduction: The main objective of this project will be the development of a statistical estimation and control framework for fractional-order systems with applications to (population) pharmacokinetics, pharmacodynamics, and drug administration. In particular: » We will propose novel parameter estimation methodologies for fractional-order systems and will explore the development of appropriate mixed-effect models for populations for patients » We will develop methodologies that will allow us to quantify the inter- and intra-patient uncertainty » We will develop control methodologies, located on model predictive control, that will allow the safe and optimal automatic administration of drugs to patients who are hospitalised (e.g., anaesthesia during surgery). Project Key Words: Pharmacokinetics; Fractional-order dynamical systems; Estimation Theory; Mixed-Effect models; Uncertainty Quantification; Control theory. Start Date: 01/10/22 Application Closing date: 28/02/22 Funding Body: DFE (tbc) Funding Information: This three year studentship, for full-time PhD study, is potentially funded by the Department for the Economy (DfE) and commences on 1 October 2022. For UK domiciled students the value of an award includes the cost of approved tuition fees as well as maintenance support (Fees £4,500 pa and Stipend rate £15,609 pa - 2022-23 rates to be confirmed). To be considered eligible for a full DfE studentship award you must have been ordinarily resident in the United Kingdom for the full three year period before the first day of the first academic year of the course. The candidate must be ordinarily resident in Northern Ireland on the first day of the first academic year of the course, normally 1 October. For more information about eligibility criteria please refer to the DfE Postgraduate Studentship Terms and Conditions 2021-22 at https://go.qub.ac.uk/dfeterms candidates should apply electronically through the Queen's online application portal at: https://dap.qub.ac.uk/portal/ Academic General Requirements: A minimum 2.1 honours degree or equivalent in Computer Science or Electrical and Electronic Engineering or significant degree is required. Skills:
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