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Job Opportunity: Postdoctoral Research Scientist - Cellular Degradation Systems Lab:Job description:Job location: London Job location: The Francis Crick Institute, Midland Road, London Summary Schreiber lab is seeking a highly motivated enthusiastic Project Research Scientist (PRS) to study the regulation of autophagy by protein phosphatases. This will involve screening candidate phosphatases by carrying out focused CRISPR-Cas9 knockout screens and subsequent functional, biochemical and/or structural characterization. The prosperous candidate will have practice in mammalian cell culture and genome editing techniques and ideally an excellent knowledge of autophagy, protein phosphatases or membrane trafficking. In the first instance this is a fixed-term position, but it can be extended further depending on progress and funding. Project Summary Autophagy initiates a fascinating cellular response by converting small vesicles into sheet-like structures which upon closure give rise to double membrane vesicles also known as autophagosomes. Fusion with the lysosome/vacuole triggers degradation of its engulfed content allowing for the recycling and repurposing of all contained cellular building blocks. This equips the cell with a remarkable capability to adapt to its ever-changing environment by maintaining cellular homeostasis despite challenging environmental conditions. Additionally, autophagy also equips the cell with the capability to neutralize potentially cytotoxic threads such as invading pathogens, damaged organelles or protein aggregates explaining the many beneficial properties attributed to autophagy for human health. Consequently, deregulation of autophagy is connected with many human diseases such as cancer, neurodegeneration and infection. Autophagy is a captivating but also very complex process which requires multiple cellular factors and layers of regulation. The individual steps involved are difficult to study solely in the crowded environment of the cell. Hence, the lab has developed a cell-free system to re-build the process of autophagosome formation in the test tube to understand when, where and how each of the components contributes to autophagosome formation. Such system can be manipulated at will, allowing us to dissect and visualize the different steps in order to gain unprecedented insights into the molecular mechanism. About us The Francis Crick Institute is a biomedical discovery institute dedicated to knowledge the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases. An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King's College London. The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe. The Francis Crick Institute will be world-class with a strong national function. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. » If you are interested in applying for this function, please apply via our website. » Closing date: 21st February 2022 » All offers of employment are subject to prosperous security screening and continuous eligibility to work in the United Kingdom. Skills:
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