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Job Offer: Lead Chemist: Oligonucleotide Synthesis and Scale UpNATA:Job description:Job location: Oxfordshire The Research adjunct will be a key member of the NATA Chemistry Team synthesising and developing new therapeutic oligonucleotides for various translational and collaborative projects. The individual will operate and maintain the oligonucleotide synthesizers, purify materials using HPLC and perform Quality Control on LC-MS. You will work with other team members to ensure the smooth running of the NATA chemistry laboratory including oligonucleotides database implementation, chemicals inventory and equipment maintenance . NATA is seeking a dynamic and accomplished individual to join as Lead Chemist,Oligonucleotide Synthesis and Scale Up. This is an exciting new function located full time at Harwell, that requires leadership abilities, initiative and drive. Reporting to the Executive Director, you will be responsible for the development of oligonucleotide synthesis capabilities while working with an inter-disciplinary team to deliver therapeutic oligonucleotides for NATA's internal and external programmes. Responsibilities » leadership abilities of a team that is responsible for delivering an efficient oligonucleotide synthesis capcapability to serve the needs of NATA's research and innovation projects on time and on budget » Management and maintenance of a cutting-edge oligonucleotide synthesis laboratory (including equipment and reagents) adhering to significant health and safety regulations » Implementation of process workflows and development of standard operating procedures to achieve consistent levels of oligonucleotide synthesis at high quality » Maintain an up-to-date expertise of new chemistries, technologies and processes significant to therapeutic oligonucleotide synthesis and scale up » Identify, evaluate and implement new technologies and undertake method development for the synthesis, purification and characterization of novel oligonucleotide conjugates » Work closely with senior colleagues to deliver NATA projects and provide input to the objectives of NATA's research and innovation strategy » Provide domain expertise skills and manage external collaborations » Undertake responsibility for the recruitment, management, training, mentorship and career development of team members » Take an active function in training, education and outreach activities About you » Bachelor's Degree (or higher) in organic chemistry, chemical biology or significant, related discipline » Significant practice and skills gained in academia or industry focussed on managing oligonucleotide synthesis capabilities, including scale up » Hands on practice in the synthesis of modified oligonucleotides » Hands on practice in oligonucleotide purification, including reverse phase and ion exchange chromatography, and oligonucleotide analytics, including LC-MS. » practice in data analysis and interpretation » practice in establishing and optimising standard operating procedures and controlling processes by adherence to quality management systems » practice in a leadership abilities function and managing a team that demonstrated high levels of productivity » Flexible and adaptable, able to manage changing priorities » Good communication skills and effective engagement with colleagues and collaborators Employee Benefits: We are offering a whole host of family friendly benefits including; 30 days holiday (plus bank-holidays), an excellent pension scheme, shopping/travel discounts, and wellbeing initiatives that enable our employees to have a great work/life balance! How to apply: For full details and to complete an application: https://mrc.tal.net/vx/lang-en-GB/mobile-0/appcentre-1/brand-3/xf-c186ab4ad 402/candidate/so/pm/4/pl/1/opp/1933-Lead-Chemist-Oligonucleotide-Synthesis-a nd-Scale-Up/en-GB The NATA is a research institute within MRC part of UK Research and Innovation. UKRI is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, for more information: www.ukri.org The closing date for applications is 7th September 2022. Skills:
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