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Job Offer: Research Associate - Genome Regulation:Job description:Job location: Cambridge The Ahringer lab in the Gurdon Institute is seeking an practiced laboratory research scientist with skills in molecular biology and genomics to support its research programmes. We decipher how chromatin and gene expression are regulated to direct the step-by-step development of the single-celled totipotent zygote to the differentiated state. We use the C. elegans model, where the invariant lineage makes it the only organism where it is feasible to determine cell-to-cell genomic regulatory transitions across development. We apply single cell profiling, bulk genomic assays, microscopy, and mutant analyses to determine how the genome is regulated to drive developmental decisions and their expression. This is a key function that will offer collaborative support and technical skills across the scientific programmes in the laboratory. The function covers a wide variety of activities, allowing for continuity of lab operations. Activities include: » Collaborating with lab members on research projects. » Providing experimental or technical support to other lab members. » Providing technical skills and input to develop, optimise and troubleshoot significant and novel methodologies. » Independently undertaking own research projects, designing, and executing experiments in consultation with the group leader. » Participating in academic activities, including group meetings and journal clubs, seminars, and scientific meetings. » Writing up findings and completing revisions. » Maintaining laboratory organisation, supplies, and safety procedures » Training new and existing lab members in standard operating procedures This is a highly collaborative position, so excellent communication and interpersonal skills are essential. You should be a motivated and organised individual with skills in a broad range of molecular biology techniques and have the capability to work both independently and as part of a team. practice in genomic profiling techniques (e.g. ChIP-seq, ATAC-seq, RNA-seq, single cell analyses) is highly desirable. Candidates should have a PhD in a significant discipline and have a capacity to apply initiative and creativity to deal with technical and biological problems. The Gurdon Institute is a world-renowned centre of Developmental biology and Cancer research embedded in the University of Cambridge. It provides an exceptional and stimulating environment that promotes collaborative and interdisciplinary research in a supportive and modern setting, with access to state-of-the-art technologies such as super-resolution imaging, single-cell analyses, genome engineering, and genomics and computer modelling. Informal enquiries can be made to Julie Ahringer via ja219@cam.ac.uk If you have any questions about this vacancy or the application process, Contact Us by hr@gurdon.cam.ac.uk. Fixed-term: The funds for this post are available until 31 December 2025 in the first instance. To apply online for this vacancy and to view more information about the function, please click the 'Apply' button above. Please quote reference PR41123 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Skills:
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