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Job Opportunity: Research Associate:Job description:Job location: London Job location: Hammersmith Campus (East Acton) Job Summary We have received British Heart Foundation funding to further our studies on m6A RNA methylation in the heart. This project will study the impact of the ?m6A writer? METTL3 methylase in the diabetic and ischaemic heart. At mechanistic level, we will focus on the impact of METTL3 on microRNA processing in human cardiac endothelial cells, prepared from clinical samples. Together with molecular and cellular studies, in vivo experiments are a fundamental part of these studies. The postholder will have a full knowledge of cardiovascular and diabetes research as well as gene therapy and regenerative medicine, and will have already prosperously worked in these areas of research during, or after, PhD studies. The postholder will combine the use of endothelial cell culture and mouse disease models to mechanistically demonstrate the therapeutic benefit of cardiac METTL-3 gene therapy in the post-MI diabetic heart. Previous excellent skills in experimental surgery (mouse LAD), histology and cell culture are essential. skills in RNA biology is also required to support state-of the art RNA-sequencing technologies tasks and responsibilities: » We are seeking for a motivated Researcher who has a wide literature knowledge in gene therapy and regenerative medicine in the setting of cardiovascular disease and diabetes. A appropriate candidate will have first-hand practice with: » In vivo mouse studies, including LAD-ligation with recovery; Histology, immunohistochemistry, confocal microscopy, and morphometric analyses on heart section » Primary culture of cardiovascular cells and cell biology assays RNA and protein analyses » The postholder will be familiar with the significant wet-lab located approaches and techniques, and have a track record of excellent research in vitro and in vivo. » They will conduct all the experiments and data analyses; and will write the papers for publication, reporting the result of this study (and revise it following input from the PI and other authors) Essential requirements This post offers an excellent opportunity for academic career advancement in one of the best global research institutions and as part of a highly regarded research group. » candidates must have a laboratory-located PhD degree, or working toward one, in a cardiovascular subject or equivalent industrial practice. Please see the job description and person specification document connected with this advert for the full list of criteria. » availability to lgain and to be flexible are essential. » The capability to interact effectively with scientists in a related discipline, including clear communication, is required. » Adequate interpersonal skills are also a key requirement, as is commitment to Equality, Diversity and Inclusion. » A commitment to data quality is essential. An knowledge of the process and importance of publishing is essential. more information This is a Fulltime, fixed term function for 14 months located at Hammersmith Campus. Candidates who have not yet been officially awarded their PhD will be appointed as a Research adjunct within the income range £40,694 - £43,888 per annum. To be considered candidates need to complete an online application. Should you require any further details on the function Contact Us by: c.emanueli@imperial.ac.uk For technical issues when applying online please emailsjobs@ic.ac.uk Closing date: 30/04/2024 Skills:
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