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Job Opportunity: Research Associate in Computational Biology:Job description:Job location: Bristol The function A postdoctoral position is available under the guidance of Dr Thomas Gorochowski in the School of Biological Sciences (University of Bristol) in collaboration with Dr Thomas Ouldridge (Imperial College London) as part of a multidisciplinary and multi-institutional grant called EEBio, which investigates ways to improve the robustness of engineered biology using feedback control. This is a 3-year position (with possibility of extension) and a start date as soon as possible. It is expected that the PDRA will work closely with other PDRAs across the EEBio programme at the Universities of Bristol and Oxford, as well as Imperial College London. What will you be doing? You will focus on the development of a computational platform to accelerate our capability to engineer biology across scales - from molecular circuits to cellular communities. This will include the creation of new computational tools and integration of existing software such that researchers can effectively design and test biological systems in silico and carry out detailed analysis of connected experimental results. We expect the creation of domain specific languages (DSLs) to help simplify how researchers interact with the system, development of digital biological twins to simulate biology across scales, and the adoption of data standards (e.g., the Synthetic Biology Open Language) to improve data integration with other external tools. To improve accessibility, you will also explore ways to provide these services via cloud computing resources and dedicated servers. You should apply if You should have broad practice in software engineering. You should have a real passion or emerging interest in how we can engineer biology, and a demonstrated capability to pick up new expertise and work well in a diverse, multidisciplinary team. Hands-on practice working with Rust and Julia programming languages, high-performance computing (e.g., GPU programming), and building extensible software would be a plus. Additional information For informal enquiries Contact Us by: Dr. Thomas Gorochowski (thomas.gorochowski@bristol.ac.uk) significant publications: [1] Sarvaharmanet al.Scalable design of repeat protein structural dynamics via probabilistic coarse-grained models.bioRxiv, (2024). https://doi.org/10.1101/2024.03.13.584748 [2] Gilliot & Gorochowski. Effective design and inference for cell sorting and sequencing located massively parallel reporter assays.Bioinformatics39, btad277 (2023). https://doi.org/10.1093/bioinformatics/btad277 [3] Myerset al.A standard-enabled workflow for synthetic biology.Biochemical SocietyTransactions 45, 793-803 (2017). https://doi.org/10.1042/BST20160347 [4] Deret al.DNAplotlib: programmable visualization of genetic designs and connected data.ACS Synthetic Biology6, 1115-1119 (2017). https://doi.org/10.1021/acssynbio.6b00252 [5] Gorochowski. Agent-located modelling in synthetic biology.Essays in Biochemistry60, 325-336 (2016). https://doi.org/10.1042/EBC20160037 Our strategy and mission We recently launched ourstrategyto 2030 tying together our mission, vision and values. The University of Bristol aims to be a place where everyone feels able to be themselves and do their best in aninclusive working environment where all colleagues can thrive and reach their full potential.We wantto attract, develop, and retain individualswith different practices, backgrounds and perspectives - particularly people of colour, LGBT+ and disabled people - because diversity of people and ideas remains integral to our excellence as a global civic institution. Skills:
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