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Job Opportunity: Research Associate:Job description:Job location: Bristol The function The post-holder will be required to work on a project entitled ?NFYA: a novel, potentially druggable, mechanosensitive mechanism of cardiac fibrosis' under Dr Mark Bond's supervision. The project is funded by the British Heart Foundation for 3 years and will involve characterization of the function played by the NFY transcription factor as a biomechanical sensor and regulator of cardiac fibroblast proliferation, in the context of cardiac fibrosis. The project will involve using a wide variety of molecular cell biology techniques, in silico molecular modelling and ex vivo experimental models. What will you be doing? The prosperous candidate will play a key function in developing this research project and ensuring its success. The research will involve the isolation of primary cultures of cardiac fibroblasts and myocardial slices, and analysis of these to characterise the regulation and function of the NFY transcription factor in the regulation of cardiac fibroblast proliferation, migration and fibrosis. You will undertake responsibility for the day-to-day management of the project, experimental design, data collection and analysis, experimental model validation and optimization, and accurate and detailed record-keeping. The post may also require you to help with some teaching and supervision of post-graduate research students. The project will require the use of a wide variety of core molecular biology and cell biology techniques including, viral and non-viral gene transfer, qRT-qPCR, cell culture, expression vector construction, gene transcription assays, protein expression analysis, and cell behaviour assays. You should apply if We welcome applications from candidates who: » Are highly motivated by cardiovascular research. » Have a PhD in the field of molecular cell biology. » Have previous research practice in functional analysis of transcription factors. » Have previous research practice in analysing cell signalling pathways. Additional information Contract type: Open ended (Fixed funding until 31/03/2027) This advert will close at 23:59 on 13May 2024. Our strategy and mission We recently launched ourstrategyto 2030 tying together our mission, vision and values. The University of Bristol aims to be a place where everyone feels able to be themselves and do their best in aninclusive working environment where all colleagues can thrive and reach their full potential.We wantto attract, develop, and retain individualswith different practices, backgrounds and perspectives - particularly people of colour, LGBT+ and disabled people - because diversity of people and ideas remains integral to our excellence as a global civic institution. Skills:
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