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Job Offer: Research Associate:Job description:Job location: Bristol The function An enthusiastic and highly motivated Postdoctoral Research Associate is required to add their skills to a team investigating immunological mechanisms that link sight-threatening uveitis and inflammatory arthritis. We have identified cytokine-regulated mechanisms that determine the pathogenic potential of T helper cells that orchestrate tissue damage in uveitis and arthritis. The project will combinein vivomodels of autoimmune uveitis and inflammatory arthritis, alongsidein vitroT cell assays, to test key mechanisms as determinants of T cell-mediated pathology. Pre-clinical studies will also test the therapeutic potential of these immune mechanisms inin vivomodels and in samples from patients with these conditions. The post is funded for 3 years in the School of Cellular and Molecular Medicine and is available from June 2024. What will you be doing? » Usein vitroCD4 T cell assays to test mechanisms that determine their pathogenic potential. » Establish models of experimental autoimmune uveitis and inflammatory arthritis to test drug interventions. » Perform RNA-sequencing, proteomic and bioinformatic analysis of immune cells. » Analyse, interpret data and discuss results routinely with the research team. » Make a considerable intellectual contribution to the project and experimental design. » Maintain a expertise of the significant scientific literature and advancements in the field. » Dissemination of research - writing papers, presenting talks and posters at national/international meetings. » Contribute to public and patient engagement activities. » Team working, contributing to research student supervision and training. You should apply if You have, or are nearing completion/submission for a PhD, in Immunology and have practice of working within vivomurine models of experimental autoimmune uveitis and inflammatory arthritis, and working with cytokines, T helper cell cultures and cutting-edge omics approaches (e.g., RNA-sequencing). You should have a proven track record for conducting and disseminating research, evidenced by publications and presentations in respected journals and conferences, respectively. Additional information For informal enquiries Contact Us by Dr Gareth Jones,g.jones@bristol.ac.uk+44 117 455 5705. It is anticipated that interviews will be held on 4th June 2024. Our strategy and mission We recently launched ourstrategyto 2030 tying together our mission, vision and values. The University of Bristol aims to be a place where everyone feels able to be themselves and do their best in aninclusive working environment where all colleagues can thrive and reach their full potential.We wantto attract, develop, and retain individualswith different practices, backgrounds and perspectives - particularly people of colour, LGBT+ and disabled people - because diversity of people and ideas remains integral to our excellence as a global civic institution. Skills:
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